Nexera X4 Ultra High-Performance Liquid Chromatograph

Ultra High-Performance Liquid Chromatograph

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Nexera X4

Performance without compromise

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    "Built on the proven technologies of the Nexera series, the next-generation Nexera X4 Ultra High Performance Liquid Chromatograph (UHPLC) delivers a new standard in analytical excellence. Its industry-leading low-dispersion design enables superior sensitivity, ultra-sharp peaks, and outstanding separation performance, while advanced fluid control technology ensures consistently reliable results — even in high-speed, ultra-high-pressure analyses.
    Designed for labs that cannot afford interruptions, reruns, or wasted solvent, the Nexera X4 combines ultra-fast gradients, exceptionally low system volume, and enhanced robustness to keep workflows efficient and dependable under pressure. Whether used with standard LC detectors or as an LC/MS front-end, it is built for peak separation efficiency and high throughput.

    This is XPLC — Extreme Performance Chromatography."

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See how the Nexera X4 fits your workflow - request details now!

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Watch: Introduction to Shimadzu's Nexera Series UHPLC systems

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  • "Improve HPLC workflow efficiency with Nexera series Analytical Intelligence, combining automated system monitoring, diagnostics, and smart readiness features for more reliable day-to-day operation
    Reduce manual setup and protect column performance with Smart Startup and FlowPilot, enabling automated system preparation, equilibration, and controlled startup for UHPLC analysis
    Prevent analysis delays with intelligent mobile phase monitoring that tracks solvent status, helps avoid runouts, and supports uninterrupted laboratory productivity"

     

 

 

Nexera X4: Explore by Topic

 

 

 

 

Key Features

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  • XPLC — Extreme Performance Liquid Chromatography with optimized low-dispersion architecture minimizes band broadening for outstanding peak shape, high resolution, and reliable high-speed analysis.
  • Designed as a powerful LC/MS front-end, with Nexflow Tubing for MS to reduce interface-related peak broadening and preserve chromatographic performance.
  • Ferrule-free, tool-free column connections with high-pressure tolerance, simplifying setup while maintaining system integrity.
  • Novel capillary cell delivers superior PDA sensitivity, improved baseline stability, and reduced dispersion for more confident detection.
  • Supports analytical miniaturization with exceptional performance on small ID columns, helping reduce solvent consumption without compromising results.
  • Greater system reliability means fewer reruns, less troubleshooting, and more dependable operation — helping labs accelerate screening and increase throughput.

Quick Specs

 

Maximum Operating Pressure 1300 bar
ECBB (5σ) 7 µl
Flow rate settings range 0.0001 to 2.0000 mL/min
Range of gradient mixing ratio
 		 0 to 100 % (0.1 % step)
Number of selectable solvents Up to 4 solvents per pump (maximum 2 pumps)
Injection cycle time ≤  6.7 seconds (under specified conditions)
Cross-contamination ≤  0.0003 % (with rinse, typically)
Sampling rate 1 to 250 Hz
PDA Linearity 3.0 AU (under specified conditions, typically)

 

Application Highlights

Discover application notes and technical guides that help you design, validate, and optimize your test methods.

 

 

 

 

 

 

Request a quote today — talk to our team!

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Explore more solutions for your analysis

Shimadzu offers a broad range of LC and SFC solutions in both analytical and preparative scale, with a variety of optical or MS detectors and suitable software solutions to meet customer requirements.

 

 

 

 

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