MultiNA II MCE-301

Microchip Electrophoresis System

multiNA II Shimadzu

Less routine time,  more sample quality

The MultiNA II is Shimadzu’s microchip based platform for the automated quality control of DNA and RNA – replacing manual, error prone workflows with a standardized, digital 
QC step. By delivering reliable integrity metrics and working with reusable chips, it reduces hands on time, late  QC failures and running costs. This lets you focus on real science, while supporting more sustainable lab operation.

 

  • Discover the new Shimadzu multiNA II MCE-301

    • Reliable sample quality
      Automated microchip electrophoresis, RNA Integrity Index and High-Sensitivity kit for dependable DNA/RNA quality
    • Simple and intuitive to use
      Intuitive software, guided workflow, removable racks and automatic sample dilution to reduce manual steps and errors
    • Smart and sustainable QC
      Reusable chips, lower energy and water consumption to save costs and resources

     
  • multiNA II MCE-301 Shimadzu

 

 


 

Automate your DNA/RNA QC — talk to our team!

 


 

 

 

Download: Full Product Brochure — MultiNA II MCE-301

multiNA II MCE-301 Shimadzu

 

 

Explore the MultiNA II brochure to see how Shimadzu’s microchip‑based DNA/RNA platform transforms manual gels into automated, standardized quality control. Download the brochure for workflows, application examples, and detailed specifications including RNA Integrity Index, high‑sensitivity kits, and reusable chips.

 

 

MultiNA II MCE-301: Explore by Topic

 

 

 

 

Features

Simple and Smart Workflow

Designed with the user in mind, MultiNA II enables efficient, reliable analysis using simple operations. The intuitive software provides clear-cut procedures for automatic analysis, significantly increasing laboratory productivity.

multiNA II MCE-301 Shimadzu

STEP 1  Reliability 
Register analysis schedule

Because sample racks can be removed from the instrument for handling, samples can be registered while making sure they are handled properly. The software allows the analysis sequence to be selected using intuitive operations. It even allows schedules to be saved, imported, and exported.

multiNA II MCE-301 Shimadzu
multiNA II MCE-301 Shimadzu

 

STEP 2  Operating Efficiency 
Place samples and reagents

Simply place the samples and reagents in the tray, insert the tray into the system, and start the analysis.

multiNA II MCE-301 Shimadzu

 


multiNA II MCE-301 Shimadzu

STEP 3  Operating Efficiency 
Click the start button

All steps from dispensing samples to rinsing the microchip are performed automatically by the system. Data is displayed successively, starting with the sample currently being analyzed, so results can be checked immediately.

multiNA II MCE-301 Shimadzu

Checking Analysis Results  Convenience 

Intuitive data analysis software enables instant confirmation of target information of interest.

Novel Functionality Achieves a New Workflow

multiNA II MCE-301 Shimadzu

 

Automated Sample Dilution

Samples can be diluted with purified water to ensure the concentration is within the quantitatable concentration range. The system can automatically dilute samples to the specified concentration level (5, 10, or 20-fold dilution)*1.

*1 Dilution functionality is supported for up to 48 samples. Tubes for dispensing diluted samples are required separately.

multiNA II MCE-301 Shimadzu

Adding Samples During Analysis

The system can be paused during an analysis to allow adding up to 120 samples. This is particularly useful when analyzing samples from multiple users because there is no need for the analyst to prepare all the samples at the same time or wait until the current analysis is finished.

multiNA II MCE-301 Shimadzu

 

Changing the Order of Gel Images

Gel images can be rearranged into any order, regardless of the actual sample analysis order.

multiNA II MCE-301 Shimadzu

 

Comparison/Analysis of Past Data

Past data can be displayed next to current data for comparison. Even data acquired using a previous model (MCE-202 MultiNA) can be loaded and analyzed*2.

*2 Data analysis is not supported for some reagent kits.

multiNA II MCE-301 Shimadzu

 Operating Efficiency 

Automatic Analysis Significantly Shortens Analysis Time

Analysis can be started after 10 minutes of preparation. Fully automatic analysis significantly shortens operating time. In addition, the system enables overnight analysis, which provides time for focusing on research or business processes.

multiNA II MCE-301 Shimadzu

 

 Reliability 

Calibration Curves Used for Automatic Prediction

Predicted sizes and concentrations are calculated automatically to provide numerically objective results. Each analysis is corrected using an internal standard reagent to provide reliable data.

multiNA II MCE-301 Shimadzu

 

 Convenience 

Convenience of Using Data

Dedicated data analysis software is equipped with a variety of functionality to support data processing based on specific applications.

Enhanced Analysis Functions

RNA

RNA Integrity Index (RII)

Extracted RNA continues to decompose as time elapses. MultiNA systems can calculate RII values as an independent method of evaluation. The correlation to integrity index values calculated by non-Shimadzu systems has a 0.95 or higher coefficient of determination value.

multiNA II MCE-301 Shimadzu

 

multiNA II MCE-301 Shimadzu

 

  • mRNA Analysis: Used for Purity Analysis

    Cas9 mRNA (4522 nt) and EPO mRNA (859 nt) mixtures prepared to 4:1, 10:1, 20:1, and 100:1 concentration ratios were analyzed using the MultiNA. The EPO mRNA was clearly detectable for all ratios.

  • multiNA II MCE-301 Shimadzu

     

DNA

DNA Fingerprinting Analysis

For analysis with a positive control, the presence/absence of each DNA fragment in samples can be determined automatically. After analysis, results can be collectively listed or shown grouped with other samples of the same type.

  • multiNA II MCE-301 Shimadzu

    Tuna PCR-RFLP Patterns

  • multiNA II MCE-301 Shimadzu

    Tuna Discrimination Patterns

User-Friendly Design

Intuitive Software

In addition to rearranging gel images, it is easy to display size prediction values as size guides (red lines) within gel images or electropherograms.

multiNA II MCE-301 Shimadzu

 

  • Removable Sample Rack

    This removable rack holds up to 96 plates. Up to 2 types of reagent kits can be loaded in a mixed arrangement.

  • multiNA II MCE-301 Shimadzu

     

Expandable Application Range

Genome Editing

Functionality for grouping analysis and molar concentration ratio analysis enables powerful support for screening genome-edited samples.

Detection of Deletion Mutations Induced by Genome Editing Tools

The availability of genome editing tools has enabled genetic modification of biological organisms. Consequently, research activity involving genome editing has expanded rapidly. Heteroduplex mobility assaying is a quick, easy, and inexpensive method for evaluating the introduction of mutations. Since electrophoresis of heteroduplex DNA tends to involve slower mobility, it can be used to determine the presence/absence of mutations and the genotype.。

multiNA II MCE-301 Shimadzu

 

  • Grouping Analysis multiNA II MCE-301 Shimadzu

    Correlation coefficient values are calculated from heteroduplex mobility assay results for each sample and then samples with the same mutation type are grouped. Consequently, discrimination between homo and hetero types and between mutation types, which had been accomplished visually, can now be detected automatically and displayed as a single list.

  • multiNA II MCE-301 Shimadzu

     

  • Molar Concentration Ratio Analysis

    By specifying the target size range, the molar concentration ratio of peaks (bands) within that size range can be calculated. The mutation activity of the designed genome editing tool can be quantitatively evaluated by analyzing HMA, Cel-I assay, PCR-RFLP, and other data.

  • multiNA II MCE-301 Shimadzu

     

multiNA II MCE-301 Shimadzu

Analytical Intelligence is a new concept for analytical devices offered by Shimadzu. It ensures systems and software are operated just like an experienced expert would, by automatically determining whether the system status and results are acceptable or not and by providing feedback to users and resolving problems. It also ensures data reliability by compensating for any differences between user instrument knowledge or experience levels.

NGS

With the high-sensitivity kit, smear analysis functionality, and RNA integr

NGS Library Quality Control

In order to obtain good results from next-generation sequencers (NGS), the distribution and concentration of sizes in the NGS library must be properly understood. The smear analysis functionality can be used to calculate the average size and concentration values. Used in combination with a high-sensitivity kit, library data can be evaluated for concentrations down to 5 pg/µL.

multiNA II MCE-301 Shimadzu

 

  • High-Sensitivity Kit

    Used in combination with a high-sensitivity kit, library data can be evaluated for low concentrations.

  • multiNA II MCE-301 Shimadzu

Genotyping

DNA fingerprinting functionality makes it easy to identify genotypes.

Determining the Type of Meat Products

If it is difficult to identify the type of meat based on its appearance and texture, then it can be helpful to determine the type genetically. For example, depending on the freshness and processing status of meat, it may be difficult to identify the type of meat, but by using PCR analysis in combination with restriction enzyme treatment, the type of meat can be determined with high accuracy.

multiNA II MCE-301 Shimadzu

 

ECO Functions, Energy Savings

MultiNA II models achieve 30 % lower power consumption than previous models. In addition, the size is 27 % shorter than previous models, making it suitable even for confined laboratory spaces. Finally, it consumes over 40 % less purified water for rinsing, which helps reduce the volume of liquid waste and its environmental impact.

multiNA II MCE-301 Shimadzu

Comparison of Power Consumption by MultiNA II and Previous Model

Energy Savings Achieved

Power consumption was reduced to 70 % of the previous model. That not only reduces running costs during analysis, but also contributes to achieving a carbon-free society by reducing CO2 emissions.

multiNA II MCE-301 Shimadzu

Purified Water Consumption by MultiNA II Compared to Previous Model

Water Savings

The purified water consumption for rinsing was reduced to less than 60 % of the previous model, which helps reduce the volume of liquid waste and its environmental impact.

multiNA II MCE-301 Shimadzu

 

Requires Less Space

The MultiNA II has a 15 % smaller footprint and is 27 % shorter than the previous model (with the front door open). That makes it easier to install and requires less laboratory space.


 

Request a quote today — talk to our team!

 


 

 

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