The comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation analysis. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible theoretical plates are achieved for LC chromatography separation. The new Nexera-e enables separation of even the most complex mixtures, providing a new level of knowledge and understanding of sample analytes. This is especially beneficial to the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products and synthetic polymers.
Separation far exceeding conventional 1D-LC
How many peaks are co-eluted under one peak? The more complex the sample, along with a high percentage of similar compounds, means there is a high probability of co-eluting compounds found under single peaks.
Even though the co-eluting compounds may be unable to be separated by mono-dimensional separation, the orthogonal two-dimensional system will provide the best possible result.
Comparison of the separation of a traditional Chinese medicine sample using Nexera-e and a conventional onedimensional LC system
As shown, the figures the unseparated compounds with the monodimensional separation system can be separated with the two-dimensional system. Moreover, in the same analysis time, Nexera-e shows more than 200 peaks versus only 74 peaks in the conventional 1D-LC system.
For Research Use Only. Not for use in diagnostic procedures.
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