Medicinal chemistry is a common practice in pharmaceutical research and development. It describes the steps in the process from target definition, lead discovery and evaluation up first studies related to metabolism, pharmacokinetics and toxicology.
The focus is set on the discovery of new drugs, mainly based on small organic molecules. Those can be the result of classic organic-chemical synthesis, out of natural products or out of the computational chemistry in combination with chemical biology, enzymology and structural biology.
Interaction of scientist’s various disciplines enables an efficient and target driven workflow. Shimadzu provides instrumentation for both analytical and preparative work used during this process.
Applications for Medicinal Chemistry
Preparative Purification of Ibuprofen and Its Related Substances by Prominence UFPLC
Preparative purification by liquid chromatography is a widely used technique applied to drug synthesis, finding effective compounds in natural products, and structural analysis of trace unknown compounds in the pharmaceutical, food product, and chemical industries. Prominence™ UFPLC system enables substantial labor-savings in preparative purification by automating not only fractionation of the target compound but also the related processes of concentration, purification, recovery, etc.
Isolation and identification of Atorvastatin degradation impurities by UFPLC
Atorvastatin is an antilipemic drug belonging to the statin class, whose reference drug is Lipitor® (trademark by Pfizer). It is used to reduce the level of lipoproteins rich in cholesterol and reduce the risk of coronary artery disease. The drug in question is commonly sought after by pharmaceutical industries that produces generic drugs, due to the fact that the drug has a high value price, it is consumed globally, and its patent expired in late 2010. Atorvastatin has been found to degrade under acid and basic conditions. Prominence UFPLC enables the fast recovery of highly purified target compounds from complex samples such as organic synthesis reaction mixtures and natural products.
Isolation and Identification of Fluticasone degradation impurities by UFPLC
Fluticasone propionate, a medium-potency synthetic corticosteroid is used typically to relive inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma. Fluticasone propionate is marked under several different brand names such as Flonase® (trademark by GSK). Fluticasone propionate is also available as combination product of Azelastine hydrochloride and Fluticasone propionate called Dymista® (trademark by Meda Pharmaceuticals Inc.), indicated in patients over 12 years old for symptomatic relief of seasonal allergic rhinitis.