Applications for Testing

 

Evaluation of Structural Strength of Semisolids Conforming to USP 915 and USP 1912 by Penetration Method

Methods for characterization of the structural strength or consistency of semisolid materials which are scheduled for inclusion in the United States Pharmacopeia USP 915 and USP 1912, are useful for understanding the performance and quality stability of various pharmaceutical products. These USP chapters have shown that comparative evaluations of characteristics between semisolid materials are possible through evaluation of structural strength. As representative characteristics of pharmaceutical products related to structural strength, the ease of application and quality of spreading of ointments and lotions, resistance to dripping of liquid preparations for external use, and ease of application of adhesives for transdermal patches can be mentioned.

 
 
 
 
 
 
 
 

Measurement of Press-Trough Package Force and Tablet Break Force

Many tablets and capsules are packaged in thin metallic (aluminum etc.) and plastic materials. This type of package is referred to as a PTP (press trough package) or PTP sheet and serves to protect the contained tablets and capsules and facilitate handling of the contents. Therefore, quality control is necessary to ensure that the package does not peel excessively, and that the tablet is not too difficult to dispense.  Here, using the Shimadzu EZ-X compact table-top universal testing machine and the TrapeziumX material testing software, we introduce an example of the adhesive strength of the PTP package, in addition to the force required to break a tablet in half.

 
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