Applications

Features

USP <467> Analysis of Residual Pharmaceutical Solvent

Residual solvents in pharmaceuticals are strictly controlled, and are categorized as Class 1 to Class 3 depending on the risk they pose to human health. The headspace GC method prescribed in USP <467> is utilized for the analysis of residual solvents. Class 1 Procedure A requires a S/N ratio ≥5 for 1,1,1-trichloroethane and a S/N ratio ≥3 for all peaks, while Class 2A requires a resolution ≥1.0 for acetonitrile and methylene chloride. The HS-10 satisfies all of these requirements.

1: 1,1-Dichloroethene
2: 1,1,1-Trichloroethane
3: Carbon tetrachloride
4: Benzene
5: 1,2-Dichloroethane
6: Acetonitrile
7: Methylene chloride GL Sciences B.V. Inertcap467 0.32Min. D. ×30m df=1. 80um

Analysis of VOCs in Water

This is an example of the analysis of 10 μg/L (10 ppb) VOCs in water using the HS-10 and an ECD. The VOCs in water can be measured with excellent reproducibility due to the high thermal stability of the HS-10.

Reproducibility of 10 ppb VOCs RSD % (n = 5)

1: 1,1-Dichloroethene 2.1
2: Dichloromethane 2.0
3: trans-1,2-Dichloroethene 2.6
4: cis-1,2-Dichloroethene 2.3
5: Chloroform 2.1
6: 1,1,1-Trichloroethane 2.6
7: Carbon tetrachloride 3.3
8: 1,2-Dichloroethane 1.9
9: Trichloroethene 2.7

10: 1,2-Dichloropropane 1.9 10: 1,2-Dichloropropane 1.9
11: Bromodichloromethane 2.4
12: cis-1,3-Dichloropropane 1.6
13: trans-1,3-Dichloropropane 1.7
14: 1,1,2-Trichloroethane 2.2
15: Tetrachloroethene 3.4
16: Dibromochloromethane 2.1
17: Bromoform 1.6
18: 1,4-Dichlorobenzene 2.8

Blood Alcohol Concentration (BAC)

The analysis of alcohols in blood is frequently performed in the fields of forensic medicine and emergency medicine. It is utilized to determine the level of drunkenness from alcohol ingestion, to evaluate criminality, and to distinguish alcohol ingestion from other medical cases. These measurements must be performed quickly and with high accuracy, demands that can be met by headspace GC.

For Research Use Only. Not for use in diagnostic procedures.

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