The main dogma of molecular biology states that DNA is transcribed into RNA, which than is translated into the amino acid sequence of an expressed protein. Knowledge about the DNA structure and sequence is important to get a better understanding about genes, protein expression and the complex regulation mechanism in cells. Analyzing the nucleic base sequence and structure determining elements of DNA and RNA is often the starting point.
Diagnosis of gene defects as cause for rare diseases and their treatments are the driving force for the development of new generation of medications, such as gene therapy. After synthesis of the special DNA or RNA pieces, the verification of their structure and sequence are the tasks to cover.
Modern vaccines based on mRNA and their productions once more underline the importance of having state of the art techniques and solutions for fast and precise analysis’.